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References

1. KD. Tripathi. Androgens and Drugs for Erectile Dysfunction. Essentials of medical pharmacology. Seventh edition. 2013. Page-304.

2. Adam M Henrie, James J Nawarskas, and Joe R Anderson. Clinical utility of tadalafil in the treatment of pulmonary arterial hypertension: an evidence-based review. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. November 2015. [Accessed on November 08th, 2023]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636095/

3. Accord Healthcare Limited. Electronic Medicines Compendium (EMC). [Revised in October 2021] [Accessed on November 08th, 2023]https://www.medicines.org.uk/emc/files/pil.8637.pdf

4. Leeford Healthcare Private Ltd. Bigfun-36.https://www.leeford.in/product/556/bigfun-36

5. Central Drugs Standard Control Organization. Tadalafil tablet 20 mg (Additional Indication). [Revised in November 2009]. Tadalafil 10mg/20mg Tablets. [Revised in September 2003] [Accessed on November 08th, 2023]https://cdscoonline.gov.in/CDSCO/Drugs

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Cialis (tadalafil) is a medication that is used to treat erectile dysfunction. It has the same active ingredient as Cialis, and it works by increasing blood flow to the penis, which helps men to get an erection. Tadalafil is the generic name of the drug, which is sold in many countries. Tadalafil comes in tablet form and is available in 5mg and 10mg doses.

Tadalafil (Cialis) is the generic name of the drug. Cialis is also known as tadalafil, which is used to treat a condition called erectile dysfunction. The medicine comes in tablet form, and is taken orally with a glass of water. It is usually taken 1 hour before sexual activity, and it can last up to 36 hours. The effect of the drug lasts for up to 36 hours.

The medicine has been shown to be effective in treating erectile dysfunction. It is available as a generic drug, and has been approved by the FDA, and has been sold in some countries worldwide.

In addition to its effect, tadalafil works by helping to increase blood flow to the penis, which helps to achieve and maintain an erection. This may cause a feeling of sexual desire, or it can be used to help to improve the ability of a man to have sex. In some cases, it may also help improve erectile function.

It is recommended that you use a daily dose of tadalafil to achieve and maintain an erection. You should not take more than one dose of the medicine daily, and you should use only one dose for the recommended time. You should also avoid taking the medicine for longer than recommended. If you have any questions about the dose of tadalafil, you should consult with your physician.

The best time to take tadalafil is between 30 minutes to one hour before sexual activity. It can be taken once a day. You can take the medicine at any time of the day. The medicine should be taken in the morning, but you can take it in the evening to help you get an erection. The best time to take tadalafil is on a daily basis.

You should not take tadalafil more than once daily. You should also avoid taking tadalafil if you are on any medication for erectile dysfunction. Tadalafil may not work as well for some people. You should discuss any of your medical conditions with your doctor before taking tadalafil.

You should not take tadalafil if you have certain medical conditions. Before you start taking tadalafil, you should tell your doctor if you have a history of heart problems, liver or kidney disease, or if you have diabetes. The dose of tadalafil can vary. Before taking tadalafil, you should tell your doctor if you are pregnant or breastfeeding. You should also talk to your doctor if you have any other health problems, such as high or low blood pressure, heart disease, a stroke, or if you have any problem with your heart, liver, or kidney.

You should not take tadalafil if you have certain health conditions, such as an allergy to tadalafil, if you have liver or kidney problems, or if you have any of the following:

  • a history of stroke or heart attack
  • an enlarged prostate
  • a condition called
  • fibroids
  • any other medication
  • a stomach or bowel disorder
  • an eye disease
  • an eye deformity
  • a tumor that is located in the nerves or blood vessels
  • a thyroid cancer
  • a kidney or liver disease
  • a thyroid disorder
  • or other medical problems
  • a history of heart attack or stroke

You should discuss your medical history with your doctor. They may need to adjust your dose or switch you to a different medicine, depending on your medical condition. You should also tell your doctor if you have any other medical problems. You should also talk to your doctor if you have any questions about the medicine you take.

You can take the medicine in the morning, but you can take it in the evening.

Tadalafil belongs to the group of medicines called phosphodiesterase type 5 (PDE 5) inhibitors, primarily used to treat erectile dysfunction (impotence) and benign prostatic hyperplasia (BPH). Erectile dysfunction is the inability to keep a hard and erect penis suitable for sexual activity. Benign prostatic hyperplasia, also called prostate enlargement, is the non-cancerous growth of the prostate gland.

Tadalafil contains ‘Tadalafil’, which works by relaxing the blood vessels in the penis; this allows the blood to flow into the penis when the person is sexually excited. Thereby, it helps to treat erectile dysfunction. Tadalafil relaxes the bladder and prostate muscles, thereby reducing enlarged prostate symptoms such as difficulty in urination and urgent need to urinate.

You are advised to take Tadalafil for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side effects, such as headache, back pain, muscle pain, pain in the legs and arms, nasal congestion, indigestion, and facial flushing. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Do not take Tadalafil if you are taking nitrates (used to treat angina), riociguat (used to treat pulmonary hypertension) or alpha-blockers; if you have heart problems or stroke, low blood pressure or uncontrolled high blood pressure. Tadalafil is not intended for use in women. Tadalafil may cause dizziness, so drive with caution. Avoid consuming alcohol as it might cause increased dizziness. Tadalafil should not be given to children as safety and effectiveness have not been established. Keep your doctor informed about your health condition and the medicines you are taking to avoid unpleasant side effects.

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Take This Medicine as Directed by the Patient The Medication should not be taken more than once every 24 hours (2 doses should not be taken more than once a day).. Cipla Tadalafil 5mg is sometimes used in patients with severe liver or kidney problems. Do not use Tadalafil 5 mg if you have severe heart or kidney problems. Cipla Tadalafil 5 mg is usually taken on an empty stomach (into a glass of water) as directed by the need to. Tadalafil should be taken a day or two before you take Tadalafil. Tadalafil 5 mg is usually taken on an empty stomach (into a glass of water) as directed by the need to. Take Cipla Tadalafil 5mg with a light meal, because Tadalafil may decrease the effect of it. Avoid taking more than one dose per day, because it may increase the risk of side effects. Avoid drinking alcohol as it may increase the dizziness and other side effects. Take the tablet before you lay in order to avoid stomach upset. Taking Cipla Tadalafil 5mg with a meal may further increase your risk of heart problems, which may increase your chances of developing a heart attack or stroke. Talk with your doctor or pharmacist if you are unable to take Cipla Tadalafil 5 mg.

Cipla Tadalafil 5mg is usually taken with a light meal, or it may further increase your risk of heart problems, which may increase your chance of developing a heart attack or stroke.

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Cialis Generic Tadalafil Solution

Cialis is available in the following dosage forms:

Cialis Generic Tadalafil 5mg

Tadalafil 5mg dosage

The Cialis 5mg dosage is a simple, just-run medicine. The recommended starting dose is 30 mg, taken as a low dose (2.5 mg) before sexual activity. Cialis 5mg may be taken with a light meal, or it may further increase your risk of side effects such as dizziness, indigestion, and headache. The maximum recommended dose is 60 mg per day, with or without food. Take the medicine 24 hours before sexual activity.

Cialis 5mg dosage

The Cialis 5mg dosage is a long-term treatment option for erectile dysfunction.

Interactions

A. Top Drug-Drug Interactions:

1.Nitrates (e.g., nitroglycerin, isosorbide dinitrate): Cialis and nitrates both lower blood pressure. Taking them together can cause a significant and potentially life-threatening drop in blood pressure (hypotension), leading to dizziness, fainting, or even heart attack or stroke. It is contraindicated to use Cialis with nitrates or recreational "poppers" (amyl nitrites).

2.Alpha-blockers (e.g., prazosin, terazosin, tamsulosin): Both Cialis and alpha-blockers relax blood vessels, which can lead to excessive blood pressure reduction when used together. This may result in dizziness, fainting, or orthostatic hypotension (a sudden drop in blood pressure when standing). If needed, your doctor may adjust the dosage or recommend spacing the medications.

3.Other antihypertensive drugs (e.g., atenolol, propranolol, enalapril, lisinopril): Cialis can enhance the blood-pressure-lowering effects of these medications. While this interaction is usually less severe than with nitrates or alpha-blockers, it can still cause dizziness or fainting in sensitive individuals. Close monitoring of blood pressure is recommended.

Other Drug-Drug interactions:

  • Ketoconazole, itraconazole (used to manage fungal infection)
  • Protease inhibitors (used to manage HIV infection) Ex. ritonavir, lopinavir
  • Phenobarbital, phenytoin, carbamazepine (medicines used for fits)
  • Rifampicin, erythromycin, clarithromycin (medicines used for bacterial infections)
  • Other medicines used to improve blood flow to the penis (Ex. sildenafil)

B. Drug-Food Interactions:

Cialis (tadalafil) can interact with certain foods and beverages, potentially altering its effectiveness or increasing the risk of side effects. Here are the key drug-food interactions to be aware of:

  1. Grapefruit and Grapefruit Juice: Grapefruit can increase the levels of tadalafil in your blood by interfering with its metabolism. This may amplify side effects, such as headaches, dizziness, or low blood pressure. Avoid consuming grapefruit or grapefruit juice while taking Cialis.
  2. Alcohol: Drinking alcohol with Cialis can enhance the blood pressure-lowering effects of the medication, leading to symptoms like dizziness, lightheadedness, or fainting. Limiting alcohol intake is recommended while using Cialis.
  3. High-Fat Meals: While Cialis can be taken with or without food, consuming it with a high-fat meal may delay its onset of action. Opt for lighter meals if rapid effectiveness is needed.
  4. Caffeine: Though not a direct interaction, combining Cialis with high caffeine intake might worsen side effects like headaches or increase heart rate in sensitive individuals.
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